Yes, Solo CAN acquire GPS during flight IF it is able to do so. A big drawback of doing it this way is that Solo thinks that "Home" is wherever it first acquired GPS, so when it Returns To Home (which it can do if it loses contact with your controller) it will return to that spot, which might be over water or a road or whatever.
To prevent this problem, what some folks here do is take off without GPS in Fly: Manual mode, but only go straight up, until GPS is acquired. Theoretically this will result in a RTH landing where you took off from. In practice, however, it's not that simple, since "straight up" is not really possible in Fly: Manual mode (without GPS to guide Solo, the ascent will only be as "straight up" as the pilot can manage manually).
Some folks swear by this method and use it all the time without any problem. I *never* do it this way, for fear of signal-loss auto-RTH "returning" to a tree (!!!).