Yes. Two backpacks. Most airlines allow two carry-ons. One usually the size of a normal roller bag and one "personal" bag. Usually a purse, computer bag, or backpack. Solo in the overhead and backpack under the seat in front of you.
I flew Delta to Honolulu. Carry it on. TSA will always secondary your drone. They will swipe and inspect the bag. Pretty standard. Then you're on your way. The Solo backpack fits in the smaller size overheads perfect. Fly safe.
I second the Solo backpack. I looked at lots of the different ones available but chose the Solo. Fits all I need and is very comfortable to carry. Straps are thick and durable and so are the zippers. The backpack even fits in the overhead of small commercial planes.